EPAS1 (Endothelial PAS Domain Protein 1)
نویسندگان
چکیده
منابع مشابه
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
Here we describe the cloning and characterization of a PAS domain transcription factor termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia inducible factor (HIF-1alpha) and lesser similarity with other members of the basic helix-loop-helix/PAS domain family of transcription factors. Like HIF-1alpha, EPAS1 binds to and activates transcription from a DNA eleme...
متن کاملEPAS 1 ( Endothelial PAS Domain Protein 1 )
Review on EPAS1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملEndothelial PAS domain-containing protein 1 (EPAS1) gene polymorphisms and response to anti-VEGF therapy in the comparison of AMD treatments trials (CATT).
Figure 1. Mean value standard deviation change of total retinal thickness (microns) from baseline in the Comparison of AMD Treatments Trials (CATT). The efficacy of the intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents bevacizumab and ranibizumab has revolutionized the treatment of neovascular age-related macular degeneration. Results from the Comparison of AMD Treatments ...
متن کاملThe PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells.
Endothelial PAS domain protein-1 (EPAS1) regulates transcription of the genes encoding erythropoietin and vascular endothelial growth factor, which are important for maintaining oxygen homeostasis. We have previously shown that plasminogen activator inhibitor-1 (PAI-1) gene expression is induced by hypoxia. In this study, we sought to determine whether PAI-1 gene expression is directly regulate...
متن کاملRAPID COMMUNICATION Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1a
Hypoxia results in adaptive changes in the transcription of a range of genes including erythropoietin. An important mediator is hypoxia-inducible factor-1 (HIF-1), a DNA binding complex shown to contain at least two basic helix-loop-helix PAS-domain (bHLH-PAS) proteins, HIF-1a and aryl hydrocarbon nuclear receptor translocator (ARNT). In response to hypoxia, HIF-1a is activated and accumulates ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2014
ISSN: 1768-3262
DOI: 10.4267/2042/54007